For effective cryosurgery, the rate of elimination of heat from the sample is more significant than just the supplement of extremely low temperatures. Slow heat decrease like cure with cotton swaps wet in refrigerant decisions become a cause of defeated reactions to osmotic fluids flowing out of the cell running to cell retention instead of necrosis.
Efficient cure demands rapid freeze as evidenced efficient with the CryoProbe
During the immense phase, cells are damaged by intracellular fluid ice crystals riving the cell membrane, protein damage and direct thermal shock. In a second stage the cell damage is due to a vascular stasis resulting in thrombosis, ischemia and cell death. In the late stage an immunologic respond due to freezing is probable to be conducted.
Virtually all biological tissues subjected to a temperature between -4 degrees F and -20 degrees F undergo cryonecrosis.
In more conventional ‘indirect’ cryosurgical curing, such as the usage of a cotton swab wet in a refrigerant decision, the energy brought(freezing power) is not dependent to push the ice-ball to the caudal extent of the lesion. Since sample is a poor thermal conductor, the forming layers of ice will encumber the capability of extreme temperatures to thread to the distal end of the lesion unless there is enough freezing strength.
With the breakthrough ‘direct’ supplement of nitrous oxide direct non-reused cartridges and exquisite micro-applicator technique of the CryoProbe, take under control over the energy brought will insure the best possible outcomes together with petty strictness.
In all conditions a second freeze in the same cure will enhance outcomes considerably.